A ratiometric fluorescent sensor for the mitochondrial copper pool.
نویسندگان
چکیده
Copper plays a key role in the modulation of cellular function, defence, and growth. Here we present InCCu1, a ratiometric fluorescent sensor for mitochondrial copper, which changes from red to blue emission in the presence of Cu(i). Employing this probe in microscopy and flow cytometry, we show that cisplatin-treated cells have an impaired ability to accumulate copper in the mitochondria.
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عنوان ژورنال:
- Metallomics : integrated biometal science
دوره 8 9 شماره
صفحات -
تاریخ انتشار 2016